Mechanisms for AAA and QoS Interaction

Proceedings of Third IEEE Workshop on Applications and Services in Wireless Networks, ASWN 2003. Bern, Switzerland, July 2-4, 2003.The interaction between Authentication, Authorization and Accounting (AAA) systems and the Quality of Service (QoS) infrastructure is to become a must in the near future. This interaction will allow rich control and management of both users and networks. DIAMETER and DiffServ are likely to turn into the future standards in AAA and QoS systems, but they are not designed to interact with each other. To face this, we propose a new Diameter-Diffserv interaction model and describe the Application Specific Module (ASM) implemented to allow this interaction. The ASM has been implemented and tested in a complete AAA-QoS IPv6 scenario

Feeding Ecology of the Blackwing Searobin Prionotus rubio (Jordan, 1886) Over the Western Continental Shelf off Alvarado, Veracruz, Mexico

Seasonal changes of food habits of the blackwing searobin Prionotus rubio were studied over the continental shelf off Alvarado, Veracruz, Mexico, from Sept. 1994 to Aug. 1995. A total of 234 stomachs (182 with identifiable food) were analyzed. Brown shrimp Farfantopenaeus aztecus, blue crab Portunus spinicarpus, and rock shrimp Sicyonia dorsalis were the main dietary items. Low values of prey diversity and dietary breadth suggest the main prey were always relatively abundant over the western continental shelf of the Gulf of Mexico. We concluded the blackwing searobin is part of a trophic guild of demersal marine fish that impact mainly on epibenthic invertebrates

Effects of beet juice supplementation in different concentrations and the importance of nitric oxide in endurance runners

More and more beetroot has been highlighted in sports, mainly in long-term aerobic modalities, due to its high concentration of nitrate (NO3- ), being an important precursor of nitric oxide (NO), providing an improvement in sports performance. The main objective of this study was to investigate the effects of acute ingestion of beetroot juice (BR), rich in NO3- in different concentrations in endurance exercise, evaluating performance, glycemic, cardiorespiratory and urinary responses of amateur runners. We hypothesized that BR would increase glucose uptake, minimize VO2max (maximum oxygen uptake), improve exercise economy and runners' performance. Nineteen male amateur runners were exposed to two conditions, ingestion of BR and PL (placebo), the individuals were divided into three groups (minimum, average and maximum concentration), being submitted to a 30-minute running test at maximum intensity, on a racetrack. Pre and posttest blood and urine samples were collected to determine glucose uptake, NO2- (nitrite) excretion, urinary pH and urinary density. Cooper's test also performed in order to assess VO2max. The main posttest results showed that through nitrite excretion there was a reduction of nitrate to nitric oxide (0 ± 0 vs 0.94 ± 0.23, P <0.05 (pre vs post)), increase in glucose uptake (139.94 ± 35.02 vs 122.88 ± 37.69, P <0.05 (PL vs BR)) and VO2max improvement(54.96 ± 6.87 vs 55.99 ± 6.88, P <0.05 (PL vs BR))], coinciding with the increase in physical performance (2972.63 ± 308.84 vs 3018.95 ± 309.29, P <0.05 (PL vs BR))]. The results found observed that beet supplementation in amateur runners increased glucose uptake, improved VO2max and running performance

Monte Carlo Simulation of Bony Heterogeneity Effects on Dose Profile for Small Irradiation Field in Radiotherapy

In the radiotherapy treatment planning of a lesion located in the head region with small field radiation beams, the heterogeneity corrections play an important role. In this work, we investigated the influence of a bony heterogeneity on dose profile inside a soft tissue phantom containing a bony material. PDD curves were obtained by simulation using the Monte Carlo code EGSnrc and employing Eclipse® treatment planning system algorithms (Batho, Modified Batho, Equivalent TAR and Anisotropic Analytic Algorithm) for a 15 MV photon beam and field sizes of 2×2 and 10×10 cm2. The Equivalent TAR method exhibited better agreement with Monte Carlo simulations for the 2×2 cm2 field size. The magnitude of the effect on PDD due to the bony heterogeneity for 1×1, 2×2 and 10×10 cm2 field sizes increases to 10, 5 and 3%, respectively

Reducción de selenito a Selenio elemental por Pantoea agglomerans

Selenium is required and essential for the growth and metabolism of several biological systems. Its transformation in the environment occurs mainly by the activity of microorganisms, able to reduce selenite into elemental Selenium. Pantoea agglomerans UC-32 reduces selenite to nanoparticles of elemental Selenium. The aims of this work were to determine the kinetics of selenite reduction and to determine the cellular localization of this activity in P. agglomerans UC-32. The selenite reducing activity of P. agglomerans UC-32 was assayed in the presence of different selenite concentrations and the decrease of selenite and appearance of elemental Selenium were evaluated. The location of this activity was studied by cellular fractioning and zymography. Results indicated that the selenite reducing enzyme saturates at low concentrations of this compound and the zymogram localized this activity in the cytoplasmic fraction and showed that NADPH is required as coenzyme. In conclusion, P. agglomerans reduces, under aerobic conditions, selenite into insoluble elemental Selenium, immobilized in the biomass and that the enzyme catalyzing this reduction is cytoplasmatic. These characteristics would allow the "green synthesis" of selenium nanoparticles which have application in the bioremediation of different contaminated matrices, such as soil or water.El selenio es esencial y requerido por distintos sistemas biológicos para su crecimiento y metabolismo. Su transformación en el ambiente ocurre principalmente por microorganismos que reducen el selenito a selenio elemental. Pantoea agglomerans UC-32 reduce el selenito a nanopartículas de selenio elemental. El objetivo de este trabajo fue determinar la cinética de reducción de selenito a selenio elemental y la ubicación celular de la actividad reductora en Pantoea agglomerans UC-32. Se ensayó la actividad reductora de P. agglomerans frente a diferentes concentraciones de selenito, evaluándose la disminución de selenito y aparición de selenio elemental. La ubicación de la actividad reductora fue estudiada por fraccionamiento celular y zimograma. Al ensayar la actividad reductora de selenito se encontró que la enzima se satura a concentraciones bajas de este compuesto y el zimograma localizó esta actividad en la fracción citoplasmática y que requiere NADPH como coenzima. En conclusión, P. agglomerans es capaz de reducir selenito a selenio elemental insoluble inmovilizado en la biomasa en condiciones aeróbicas y que la enzima que cataliza esta reducción se localiza en la fracción de citoplasmática. Estas características permitirían la "síntesis verde" de nanopartículas de selenio las cuales tienen aplicación en la biorremediación de diferentes matrices, como suelo o agua contaminadas

GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis–van Creveld syndrome

Peer reviewe

Phylogeographic analysis reveals multiple international transmission events have driven the global emergence of Escherichia coli O157:H7

This work was supported by: Scotland by Food Standards Scotland [Grant Number FS102029] and University of Aberdeen; New Zealand, Institute of Environmental Science and Research; Canada, the Public Health Agency of Canada; United States, United States Department of AgriculturePeer reviewedPostprin

Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems

Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) (FAPESP Refs. No. 2016/08884-3 (Project PneumoPhageColor) and 2016/12234-4 (Project TransAppIL)) is hereby gratefully acknowledged. Funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Ref. No. 2016/16641-3) in the form of an MSc fellowship granted to Liliam Harada is hereby gratefully acknowledged. This work also received support from CNPq, National Council for Scientific and Technological Development, Brazil, in the form of Research Productivity (PQ) fellowships granted to Victor M. Balcão (Refs. No. 306113/2014-7 and 308208/2017-0).info:eu-repo/semantics/publishedVersio

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations